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Hepatic Venous Blood Flow Distribution in the Total Cavopulmonary Connection: Patient-Specific Anatomical Models

[+] Author Affiliations
Lakshmi Dasi, Ajit Yoganathan

Georgia Institute of Technology, Emory University, Atlanta, GA

Kerem Pekkan

Carnegie Mellon University, Pittsburgh, PA

Kevin Whitehead, Mark Fogel

The Children’s Hospital of Philadelphia, Philadelphia, PA

Paper No. SBC2007-176392, pp. 491-492; 2 pages
doi:10.1115/SBC2007-176392
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

CFD modeling of the anatomical pathways (TCPC) created by the palliative single-ventricle heart defect surgeries is an area studied by several research groups [1–5]. To the best of our knowledge except Walker et al. (in idealized experimental models) [6], all studies focused on the prediction of hydrodynamic power losses or dissipation function and ignored venous hepatic flow distribution to the left and right lungs. Hepatic flow coming from the inferior vena cava (IVC) transports essential growth factors that are required for normal lung growth. Inadequate IVC blood distribution also cause protein loosing enteropathy [7], a serious complex pathology leading to total failure of the surgically created single-ventricle circulation system. Early TCPC configurations distributing the hepatic flow unidirectionaly to one of the lungs [8] were promptly discontinued from the operating rooms and replaced with “+” shaped connections for these reasons, Fig 1.

Copyright © 2007 by ASME
Topics: Liver , Blood flow

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