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Hemodynamics and the Natural History of Cerebral Aneurysms

[+] Author Affiliations
Juan R. Cebral

Gerorge Mason University, Fairfax, VA

Marcelo A. Castro

George Mason University, Fairfax, VA

Christopher M. Putman

Inova Fairfax Hospital, Falls Church, VA

Paper No. SBC2007-176383, pp. 489-490; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


The mechanisms responsible for the evolution and rupture of cerebral aneurysms are not well understood. This is a multi-factorial problem, and previous studies [1–3] have identified the major factors involved: a) arterial hemodynamics, b) mechanobiology and wall biomechanics, and c) peri-aneurysmal environment. In this paper we present recent results based on patient-specific computational hemodynamics models of a number of cerebral aneurysms that indicate that hemodynamics plays an important role both in the progression and rupture of intracranial aneurysms. In particular, the data seems to support the idea that mechanisms associated to high wall shear stress may be responsible for the evolution and rupture of these aneurysms [4].

Copyright © 2007 by ASME



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