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Strain Distribution Over Plaques in Human Coronary Arteries Relates to Shear Stress

[+] Author Affiliations
Frank J. H. Gijsen, Johan C. H. Schuurbiers, Antonius F. W. van der Steen, Patrick W. Serruys

ErasmusMC, Rotterdam, The Netherlands

Jolanda J. Wentzel

Erasmus MC, Rotterdam, The Netherlands

Paper No. SBC2007-176313, pp. 479-480; 2 pages
doi:10.1115/SBC2007-176313
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

It is well established that atherosclerotic plaques generally develop in low shear stress regions, including curved arterial segments and bifurcations. Once these plaques intrude into the lumen, the shear stress they are exposed to alters with hitherto unknown consequences. We hypothesize that in the more advanced stages of the disease, shear stress has an important impact on plaque composition in such a way that high shear stress enhances plaque vulnerability through its biological impact on the endothelium. We investigated this hypothesis by studying the relationship between shear stress and strain, a marker for plaque composition, in human coronary arteries.

Copyright © 2007 by ASME

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