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Plaque and Shear Stress Distribution in Human Coronary Bifurcations: a Multi-Slice Computed Tomography Study

[+] Author Affiliations
Alina G. van der Giessen, Antonius F. van der Steen, Pim J. de Feyter, Frank J. Gijsen

ErasmusMC, Rotterdam, The Netherlands

Jolanda J. Wentzel

Erasmus MC, Rotterdam, The Netherlands

Frans N. van de Vosse

Eindhoven University of Technology, Eindhoven, The Netherlands

Paper No. SBC2007-176309, pp. 477-478; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


It is generally accepted that early atherosclerosis develops in low shear-stress (SS) regions such as the outer wall of arterial bifurcations and the inner bend of curved vessels (1). However, in clinical practice, it is common to observe atherosclerotic plaques at the flow-divider, or carina, of coronary bifurcations (2). Plaques at the carina are more frequently found in symptomatic patients, and may represent a more advanced stage of atherosclerosis. The carina is located in a region which is exposed to high SS. We hypothesize that if plaques are located in atheroprotective high SS regions, they have grown circumferentially from the atherogenic low SS regions.

Copyright © 2007 by ASME



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