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Development of a Discrete Finite Element Cell Model

[+] Author Affiliations
Karen M. Coghlan, Patrick McGarry, Peter E. McHugh

National University of Ireland, Galway, Galway, Ireland

Mohammad R. K. Mofrad

University of California, Berkeley, Berkeley, CA

Paper No. SBC2007-176734, pp. 437-438; 2 pages
doi:10.1115/SBC2007-176734
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Computational models have proven useful in the study of cell mechanics and mechanotransduction. While most finite element (FE) models of cells are commonly described in terms of the laws of continuum mechanics, a model that can accurately represent the microstructure of the filamentous network of the cytoskeleton would be required to relate mechanics to biology at the microscale level. An alternative approach to a continuum is presented here, whereby the discrete nature of the cytoskeleton of the cell is emphasized and the known structural properties of the cytoskeleton of the cell are utilized.

Copyright © 2007 by ASME

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