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Effect of Neutrophils Retention Time in Capillaries on Increase in Their Concentration in a Lattice Capillary Network Model

[+] Author Affiliations
Atsushi Shirai, Toshiyuki Hayase

Tohoku University, Sendai, Miyagi, Japan

Paper No. SBC2007-176717, pp. 431-432; 2 pages
doi:10.1115/SBC2007-176717
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Neutrophils are known as the most popular cells in leukocytes, and play important roles in immune system. They are retained in pulmonary capillary network even in normal lungs, causing higher concentration than in systemic circulation due to their low deformability [1]. The lungs can be a route for pathogenic substances to invade the host, since thickness of septa which separates blood and outer air is extremely thin. However, the highly concentrated neutrophils are thought to be effectively recruited to the sites of inflammation for the host defense. Therefore, it is essential to know how neutrophils flow in pulmonary capillary microvasculature for the understanding of their functions and behavior in immune system.

Copyright © 2007 by ASME

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