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Biphasic Structure-Based Modeling of Tissue Equivalent Mechanics

[+] Author Affiliations
Preethi L. Chandran

University of California at Berkeley, CA

Triantafyllos Stylianopoulos, Victor H. Barocas

University of Minnesota, MN

Paper No. SBC2007-176616, pp. 409-410; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


The collagen gel has been extensively studied as an in vitro model for soft tissue mechanics, cell-ECM interactions, and as a prototypical bioartificial tissue; a model of gel mechanics from a microstructural perspective is important for all of these [1]. An earlier experimental study recorded the microstructural rearrangements during confined compression by interpreting the evolution of birefringence patterns within the gel [2]. The patterns suggested that strain was transmitted by fiber rotation at interconnections and was non-uniform due to fluid permeation resistance, indicating that macroscopic gel mechanics arise from elastic interactions between the solid phase fibers and viscous interactions with fluid. A structure-based mathematical model to account for both the elastic and viscous response of tissue equivalents was developed.

Copyright © 2007 by ASME



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