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A Molecular Modelling Approach for Designing Bioartificial Membranes for Clinical Use With Tailored Transport Properties

[+] Author Affiliations
Mariana Ionita, Alfonso Gautieri, Emiliano Votta, Alberto Redaelli

Politecnico di Milano, Milan, Italy

Paper No. SBC2007-176371, pp. 369-370; 2 pages
doi:10.1115/SBC2007-176371
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

There has been a demand for hemodialysis membranes with better biocompatibility, the use of which would reduce the incidence of complications in patients who have been under long hemodialysis treatment. Recently, highly biocompatible membranes have been obtained by blending synthetic and polymers [1]. Specifically, poly(vinyl-alcohol) (PVA) and poly(acrylic acid) (PAA) have been combined with chitosan (Chi) and dextran (Dex) to create a biomaterials with excellent biocompatibility and mechanical properties. In this work we present a computational method based on molecular mechanics (MM) and dynamics (MD) techniques have been combined with an experimental studies, with the aim of designing and forecasting the permeability and diffusion properties of these membranes to small molecules, as a function of their composition.

Copyright © 2007 by ASME
Topics: Design , Modeling , Membranes

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