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Computational Analysis of Atherosclerotic Plaque Vulnerability Due to Hemodynamic Effects

[+] Author Affiliations
Ramses Galaz, Valerie Pazos, Richard Leask

McGill University, Montreal, QC, Canada

Rosaire Mongrain

McGill University, Montreal, QC, CanadaMontreal Heart Institute, Montreal, QC, Canada

Jean Claude Tardif

Montreal Heart Institute, Montreal, QC, Canada

Paper No. SBC2007-176045, pp. 335-336; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


Atherosclerotic plaque rupture has been extensively associated with acute myocardial infarctions, the leading cause of death in developed countries. When a plaque ruptures in the coronary arteries, it often leads to a clot formation that restricts the flow of blood downstream of the coronaries causing damage to the myocardial tissue. Hemodynamic factors combined with certain plaque morphologies and material properties play an important role in the mechanical failure of the plaque [1]. It is essential for clinicians to understand the vulnerability of plaques and the particular physiological conditions that lead to their mechanical failure. Our study focused on understanding the physical interaction between blood flow, plaque morphology and tissue properties to assess the plaque’s degree of vulnerability.

Copyright © 2007 by ASME



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