Full Content is available to subscribers

Subscribe/Learn More  >

Numerical and Experimental Analysis of Articular Chondrocyte Deformation: Calibration of a Multiscale Finite Element Model

[+] Author Affiliations
Scott L. Bevill

Stanford University, Stanford, CA

Paul L. Briant, Thomas P. Andriacchi

Stanford University, Stanford, CAPalo Alto Veterans Affairs, Palo Alto, CA

Paper No. SBC2007-175554, pp. 321-322; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


Mechanical loading of chondrocytes in isolation [1] and of articular cartilage in culture [2] has been reported to be a potent regulator of chondrocyte metabolism. Experimental studies have related tissue-level and cell-level strains in mechanically loaded cartilage explants [3], but cannot be readily extended to address more physiologic loading cases. Numerical models, which might address this need, have primarily been axisymmetric [4, 5] or two-dimensional [6] and have idealized chondrocyte geometry. Given the complexity of the mechanism of the load transfer between the tissue and cell, however, there remains a lack of information regarding the in vivo level of cell stresses and strains. Thus, the purpose of this study was to develop a multiscale experimental/numerical approach to calibrate a three-dimensional finite element (FE) model of a chondrocyte based on experimentally derived chondrocyte morphology and deformation data. The method was than applied to determine the modulus of a chondrocyte located in the superficial zone.

Copyright © 2007 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In