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Multi-Scale Models of Epithelial Cell Injury and Detachment During Microbubble Flows

[+] Author Affiliations
Hannah L. Dailey, Huseyin C. Yalcin, Samir N. Ghadiali

Lehigh University, Bethlehem, PA

Paper No. SBC2007-176497, pp. 291-292; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


Certain pathological conditions, e.g. pneumonia or acute lung injury, can lead to fluid buildup in the small pulmonary airways. During breathing, micron-sized air bubbles propagate through the fluid-occluded airways and these microbubbles may exert injurious hydrodynamic stresses on the epithelial cells (EC) which line airway walls. Specifically, the pressure and shear stresses generated during microbubble flows may cause plasma membrane rupture [1], cell detachment [2] and an exacerbation of the existing lung injury.

Copyright © 2007 by ASME



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