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The Role of Microtubule Organization in Chondrocyte Response to Osmotic Loading

[+] Author Affiliations
Elizabeth S. Oswald, Pen-hsiu Grace Chao, J. Chloe Bulinski, Gerard A. Ateshian, Clark T. Hung

Columbia University, NY, NY

Paper No. SBC2007-176634, pp. 277-278; 2 pages
doi:10.1115/SBC2007-176634
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

The cytoskeleton, including actin filaments and microtubules, provides chondrocytes with structure, cytoplasmic organization, and intracellular transport. The cytoskeleton is known to be involved in cellular responses to physiologic mechanical and osmotic loading signals, including morphological changes and mechanostransduction [1, 2]. Here, we examine microtubule (MT) involvement in volume response of chondrocytes to osmotic loading, as well as organization of stable MT with hypoosmotic loading. We also explore the hypothesis that chondrocytes from different zones of cartilage possess cytoskeletons with different properties, which help explain variations in their volume response to osmotic loading in situ and in vitro [3].

Copyright © 2007 by ASME
Topics: Chondrocytes

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