0

Full Content is available to subscribers

Subscribe/Learn More  >

Stretch-Activated Calcium Signal Propagation Following Mechanical Stimulation of Focal Adhesions

[+] Author Affiliations
Warren C. Ruder, Erica D. Pratt, Philip R. LeDuc, James F. Antaki

Carnegie Mellon University, Pittsburgh, PA

Nailah Z. Brandy

Carnegie Mellon University, Pittsburgh, PAUniversity of the Virgin Islands, St. Thomas, VI

David A. LaVan

Yale University, New Haven, CT

Paper No. SBC2007-176431, pp. 271-272; 2 pages
doi:10.1115/SBC2007-176431
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Cells translate environmental mechanical stimuli into biochemical reactions that govern a range of cellular processes such as proliferation, death and tissue matrix remodeling. Mechanical activation of individual focal adhesions formed between the cell and its environment directly correspond to several internal responses. Intracellular calcium concentration, [Ca2+]in, has been shown to profoundly change during force sensing. In order to understand this dynamic in cells, we compared calcium mobilization resulting from chemical stimulation and that resulting from mechanical stimulation. We have analyzed the response of fibroblasts to membrane displacements of over 5 μm resulting in eventual spikes in [Ca2+]in. Our data initially indicates that fibroblasts may process mechanical calcium events in unique manner in comparison to other cell types. This finding has implications in a range of fields including mechanobiology and magnetics based activation.

Copyright © 2007 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In