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Micromechanical Analysis of Tissues: The Effect of Cell Adhesion to Extra Cellular Matrix

[+] Author Affiliations
N. Abolfathi, G. Karami, M. Ziejewski

North Dakota State University, Fargo, ND

Paper No. SBC2007-176270, pp. 269-270; 2 pages
doi:10.1115/SBC2007-176270
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5

abstract

Modeling of interactions between cell and extra cellular matrix (ECM) is essential in a cell and tissue injury study. Several studies have been conducted to realize the role of mechanical property of a cell and ECM in a tissue exposed to an external loading. In this study we have used a micromechanical approach by assuming two representative volume elements (RVE) with different packing of cell inside the matrix to characterize the mechanical property of the composite formed by the cell and the ECM in a tissue. In the micromechanical modeling procedure, the cell-ECM adhesion will be studied in detail. The results will clarify the role of cell adhesion in load transferring characteristics inside the cell – ECM composite.

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