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Platelet and Shear Stress Interactions Within Asymmetric Stenotic Arteries

[+] Author Affiliations
Jeff Shrum, Richard L. Leask

McGill University, Montreal, QC, CanadaMontreal Heart Institute, Montreal, QC, Canada

Yahye Merhi

Montreal Heart Institute, Montreal, QC, Canada

Paper No. SBC2007-176446, pp. 203-204; 2 pages
doi:10.1115/SBC2007-176446
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Under normal physiological conditions platelets circulate in the plasma of blood and respond to vessel injury by changing shape, secreting granule contents and aggregating [1]. The activation of platelets in diseased or occluded arteries can form thrombosis causing a heart attack or stroke [2]. Shear stress activation has been suggested as an important contributor to increased platelet activation and adhesion seen in regions of stenosis.

Copyright © 2007 by ASME

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