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Dynamics of Arterial Remodeling in Response to a Sustained Step Change in Blood Flow Using a Constituent-Based Model

[+] Author Affiliations
Alkiviadis Tsamis, Nikos Stergiopulos

École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Paper No. SBC2007-176359, pp. 193-194; 2 pages
doi:10.1115/SBC2007-176359
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

The arterial wall undergoes substantial remodeling whenever the local blood flow changes for more than a few days [1]. An increase in flow causes an increase in inner radius, which occurs in two phases and tends to restore the baseline levels of intimal shear stress [2]. Firstly, an acute dilation of the artery occurs due to relaxation of vascular smooth muscle (VSM) cells [3]. Secondly, a long-term media reconstruction takes place, during which VSM cells migrate and proliferate circumferentially causing an increase in undeformed lumen. Moreover, arterial wall thickens to restore the altered wall stress [4].

Copyright © 2007 by ASME

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