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Culture Medium With Blood Analog Mechanical Properties

[+] Author Affiliations
Chantal N. van den Broek, Marcel C. M. Rutten, Frans N. van de Vosse

Eindhoven University of Technology, Eindhoven, The Netherlands

Ole Frøbert

University of Aarhus, Aarhus, Denmark

Paper No. SBC2007-176336, pp. 189-190; 2 pages
doi:10.1115/SBC2007-176336
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Culture of arteries has become increasingly important in studying atherosclerosis and the effect of clinical interventions [1]. Ideally, arterial culturing should imitate in vivo conditions within an ex vivo environment. Physiological wall shear stresses are important as they induce an atheroprotective endothelial phenotype [2], which is relevant for maintaining arterial wall integrity. The arteries in such ex vivo studies, however, are perfused with culture medium, which has a viscosity lower than blood. Previously, the culture medium has been supplemented with dextran to obtain physiological fluid viscosity and wall shear stresses. However, several researchers [3,4] reported side effects of dextran on the cells in the arterial wall independent of its effect on medium viscosity. Also, dextran increases medium osmolality to supraphysiological levels [5]. This suggests that dextran may not be the optimal substance to increase medium viscosity.

Copyright © 2007 by ASME

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