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Different Strains of Mice Exhibit Different Aortic Arch Geometry and Plaque Distribution: A Fluid Dynamic Effect

[+] Author Affiliations
Hui Zhu, Jessica Shih, David S. Long, Morton H. Friedman

Duke University, Durham, NC

John R. Hagaman, Nobuyo Maeda

University of North Carolina at Chapel Hill, Chapel Hill, NC

Paper No. SBC2007-175844, pp. 151-152; 2 pages
doi:10.1115/SBC2007-175844
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

In earlier work, we observed different patterns of disease distribution in the aortic arches of apolipoprotien E (apoE)-deficient C57BL/6 (B6) and 129/SvEv (129) mouse strains [1]. In the relatively young mice (6 mo old), fatty plaques are seen mainly in the aortic root area, extending into the right innominate artery (RIA), with very little plaque in the more distal aortic arch in the B6 strain. However, in the 129 strain, plaques are found more in the inner curvature of the aortic arch but less in the sinus area than in B6 strain (Fig. 1).

Copyright © 2007 by ASME

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