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Non Invasive Assessment of Leaflet Deformation in Heart Valve Tissue Engineering

[+] Author Affiliations
Jeroen Kortsmit, Niels J. B. Driessen, Marcel C. M. Rutten, Frank P. T. Baaijens

Eindhoven University of Technology, The Netherlands

Paper No. SBC2007-175643, pp. 143-144; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


Contemporary tissue engineered heart valves seem to have sufficient mechanical strength for implantation [1]. Nevertheless, mechanical properties, tissue structure and architecture still need to be improved. Recent studies indicate enhancement of mechanical properties by applying cyclic diastolic pressure loads to the developing tissue in a bioreactor system [2]. However, current bioreactors operate with a preset transvalvular pressure applied to the tissue. Mechanical properties of the engineered construct may vary during culturing and consequently, the pressure-induced deformations are unknown. To systematically study the effects of mechanical straining on tissue development and to design an optimal conditioning protocol, real-time measurement and control of local tissue strains are desired.

Copyright © 2007 by ASME



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