0

Full Content is available to subscribers

Subscribe/Learn More  >

Fickian Behavior and Concentration-Dependence of the Diffusion of Dextran in Agarose

[+] Author Affiliations
Michael B. Albro, Vikram Rajan, Clark T. Hung, Gerard A. Ateshian

Columbia University, New York, NY

Paper No. SBC2007-176646, pp. 1061-1062; 2 pages
doi:10.1115/SBC2007-176646
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Various studies have attempted to quantify the effects of loading on nutrient transport in cartilage and other soft tissues. The application of a dynamic mechanical stimulus has been shown to significantly enhance the mechanical properties of chondrocyte-seeded agarose [1]. While the mechanism for this enhancement is still not completely understood, dynamic loading has been shown theoretically [2] as well as experimentally [3] to increase the uptake of large molecules. Since dextran is available in a wide range of molecular weights and can be conjugated with fluorphores, it has become a popular model system for studying solute transport in statically loaded and free swelling gels and tissues [4, 5]. To better characterize this model system, this study uses fluorescence recovery after photobleaching (FRAP) to investigate the Fickian behavior of linear dextran macromolecules as well as the dependence of its diffusivity on concentration.

Copyright © 2007 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In