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Effects of Anomalous Diffusion Mechanisms in Developing Tissue Engineered Constructs

[+] Author Affiliations
Gabriel Chao, Cees Oomens, Rene van Donkelaar, Frank Baaijens

Eindhoven University of Technology, Eindhoven, the Netherlands

Paper No. SBC2007-176507, pp. 1059-1060; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


Many diffusive processes in biological systems refuse to obey the standard laws of diffusion. In normal diffusion, the diffusivity can be considered constant and the concentration of the diffusive particles follows Fick’s law. However, in highly heterogeneous materials such as tissues, the complex microgeometry of the medium imposes serious restrictions to the mobility of the particles. This scenario is known as anomalous diffusion. Experiments in diverse biological systems including diffusion in the extracellular space of the brain [1], morphogen movement in the extracellular environment [2], protein movement inside cells [3], identified anomalous, rather than Fickian, transport.

Copyright © 2007 by ASME



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