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Cellular Deformations in Microintegrated Electrospun Poly (Ester Urethane) Urea Scaffolds Under Biaxial Stretch

[+] Author Affiliations
Jun Liao, W. David Merryman, Yi Hong, John Stella, Simon Watkins, William R. Wagner, Michael S. Sacks

University of Pittsburgh, Pittsburgh, PA

Paper No. SBC2007-176726, pp. 1047-1048; 2 pages
doi:10.1115/SBC2007-176726
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Recently, vascular smooth muscle cells (SMCs) have been electrosprayed concurrently with electrospun biodegradable elastomeric poly (ester urethane) urea (PEUU) to form cell-microintegrated scaffolds [1]. These scaffolds exhibit soft tissue-like elastomeric mechanical properties [2], and are thus promising candidates for repair or replacement of diseased cardiovascular tissues. The level of cellular deformation during in vitro mechanical training will likely influence the extracellular matrix formation. However, these deformations are likely complex and dependent upon both scaffold properties and the cellular interactions with the local fibers. Our objective is to quantify microintegrated cellular deformations in response to biaxial scaffold stretches, using the nuclear aspect ratio (NAR) as an index of overall cellular deformation.

Copyright © 2007 by ASME

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