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Microvascular Oreintation During Angiogenesis: Effects of Mechanical Stretch and Boundary Conditions

[+] Author Affiliations
Laxminarayanan Krishnan, Clayton J. Underwood, Steve A. Maas, Benjamin Ellis, Tejas C. Kode, Jeffrey A. Weiss

University of Utah, Salt Lake City, UT

James B. Hoying

University of Arizona, Tucson, AZ

Paper No. SBC2007-176598, pp. 1033-1034; 2 pages
doi:10.1115/SBC2007-176598
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Mechanical forces affect the behavior of a variety of cell types including fibroblasts, chondrocytes, osteoblasts, smooth muscle cells, and endothelial cells. In vitro cellular orientation is primarily achieved through cell-generated mechanical forces or contact guidance. Endothelial cell (EC) cords align both normal to the stretch direction as well as along pre-tensioned collagen matrices. Confluent ECs orient parallel to grooved surfaces while tractional forces generated by ECs contract the matrix aligning collagen fibers, which in turn are considered a guiding scaffold. The influence of mechanical forces and boundary conditions on the growth and proliferation of microvessels during the process of angiogenesis is unknown. A better understanding of these interactions is essential both from a basic science standpoint as well as in the engineering of artificial vascularized matrices with specific orientation of vessels and endothelial cells. The objective of this study was to examine the role of internal and external mechanical forces in microvessel orientation during angiogenesis using an in vitro model of angiogenesis.

Copyright © 2007 by ASME

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