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Defined Medium for the Self-Assembling Process: Enhancing Functionality of Tissue Engineered Articular Cartilage

[+] Author Affiliations
Christopher M. Revell, Kyriacos A. Athanasiou

Rice University, Houston, TX

Paper No. SBC2007-176440, pp. 1015-1016; 2 pages
doi:10.1115/SBC2007-176440
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

A self-assembling process has recently been developed that produces tissue engineered articular cartilage constructs of clinically-relevant dimensions with mechanical properties approaching one-third of native values [1]. These constructs, however, are cultured in 10% fetal bovine serum (FBS), which if eliminated, will make them more desirable as an in vitro cartilage replacement towards a translational approach. To this end, this study sought to assess the quality of self-assembled articular cartilage constructs exposed to varying amounts of FBS as well as a serum substitute that has recently been found to induce chondrogenic differentiation and increase cell proliferation [2].

Copyright © 2007 by ASME

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