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Modeling and System Identification of Arterial Hemodynamics in Humans

[+] Author Affiliations
Mohammad Rashedi, Alyssa Chappell, Shaohua Wang, Roderick MacArthur, M. Sean McMurtry, Barry Finegan

University of Alberta, Edmonton, AB, Canada

Nima Fazeli, Jin-Oh Hahn

University of Maryland, College Park, MD

Paper No. DSCC2013-3848, pp. V003T43A003; 8 pages
  • ASME 2013 Dynamic Systems and Control Conference
  • Volume 3: Nonlinear Estimation and Control; Optimization and Optimal Control; Piezoelectric Actuation and Nanoscale Control; Robotics and Manipulators; Sensing; System Identification (Estimation for Automotive Applications, Modeling, Therapeutic Control in Bio-Systems); Variable Structure/Sliding-Mode Control; Vehicles and Human Robotics; Vehicle Dynamics and Control; Vehicle Path Planning and Collision Avoidance; Vibrational and Mechanical Systems; Wind Energy Systems and Control
  • Palo Alto, California, USA, October 21–23, 2013
  • Conference Sponsors: Dynamic Systems and Control Division
  • ISBN: 978-0-7918-5614-7
  • Copyright © 2013 by ASME


This paper seeks to determine the validity of two distinct tube-load models relating central aortic blood pressure to peripheral blood pressure in humans. Specifically a single-tube model (1-TL) and a serially connected two-tube (2-TL) model, both terminating in a Windkessel load, are considered as representations of the central aortic-peripheral arterial path. The validity and fidelity of the two models was assessed and compared quantitatively by fitting central aortic, radial and femoral blood pressures collected from 8 patients. Both models fitted the BP waveform pairs effectively, and were capable of estimating pulse travel time (PTT) accurately; also the model derived frequency responses were close to the empiric transfer function estimates derived from central and peripheral BP measurements. The 2-TL model was consistently better than 1-TL with statistical significance in terms of accuracy of the central aortic BP waveform, the average waveform RMSE were 2.52 mmHg versus 3.24 mmHg respectively (p<0.05).

Copyright © 2013 by ASME



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