Full Content is available to subscribers

Subscribe/Learn More  >

Enhanced Damage Effects Induced by Cell-Level Hyperthermia With Higher Heating Rate or Allied Cooling Procedure

[+] Author Affiliations
Chao Jin, Li Ting Yi

Tsinghua University, Beijing, China

Jing Liu

Tsinghua University, Beijing, ChinaChinese Academy of Sciences, Beijing, China

Paper No. MNHMT2013-22132, pp. V001T13A003; 5 pages
  • ASME 2013 4th International Conference on Micro/Nanoscale Heat and Mass Transfer
  • ASME 2013 4th International Conference on Micro/Nanoscale Heat and Mass Transfer
  • Hong Kong, China, December 11–14, 2013
  • Conference Sponsors: Heat Transfer Division
  • ISBN: 978-0-7918-5615-4
  • Copyright © 2013 by ASME


As a core basis, the knowledge of cellular thermal responses is critical to understand the thermal damage mechanism of hyperthermia. In the aid of a cryo-stage system with controlled temperature ranging from −196°C to 125°C, the present work is dedicated to investigate the thermal behaviors of cancer cells (i.e. MCF-7 cells) subject to hyperthermia with a higher heating rate or allied with a rapid cooling procedure. The preliminary results show the following factors: (1) The MCF-7 cells show potential enhanced sensitivity to heat when the heating rate increases from 10 °C/min to 30°C/min; (2) The enhanced degree of thermal damages induced by the higher heating rate is time dependent; (3) The rapid cooling procedure following the hyperthermia would be another effective way to strengthen the killing effects of cancer cells. In addition, further microscopic experiments have also been implemented to observe the morphological changes of cells induced by the rapid heating treatment. The present study partly promotes the mechanistic understandings of cellular damage through an alternative heating approach, which would provide a valuable reference to improve the therapeutic efficiency in the coming time.

Copyright © 2013 by ASME
Topics: Cooling , Heating , Damage



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In