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A Custom Image-Based Analysis Tool for Quantifying Elastin and Collagen Fiber Micro-Architecture in the Wall of the Human Aorta From Multi-Photon Microscopy Images

[+] Author Affiliations
Ryan G. Koch, Alkiviadis Tsamis, William R. Wagner, David A. Vorp

University of Pittsburgh, Pittsburgh, PA

Antonio D’Amore

University of Pittsburgh, Pittsburgh, PAFondazione Ri.MED, Palermo, Italy

Paper No. SBC2013-14482, pp. V01BT58A005; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5561-4
  • Copyright © 2013 by ASME


The two primary load-bearing components of the connective fiber micro-architecture of aorta are the proteins elastin and collagen. The structure of elastin and collagen fibers is important to support the proper function of the aorta, and alteration of the quantity and/or arrangement of these fibers can lead to mechanical and functional changes associated with aortic disease. Therefore, an adequate quantification of the micro-architecture of elastin and collagen fibers in the aortic wall would provide insight into the influence of micro-architecture on the biomechanical response of the aorta in health and disease.

Copyright © 2013 by ASME
Topics: Photons , Fibers , Microscopy , Aorta



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