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Effect of Vascular Convexity on Diffusive Delivery of Blood-Borne Substances in Normal and Tumor Tissues

[+] Author Affiliations
James Baish

Bucknell University, Lewisburg, PA

Paper No. SBC2013-14130, pp. V01AT21A001; 2 pages
doi:10.1115/SBC2013-14130
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

Blood-borne substances such as oxygen, nutrients, drugs and particles arrive at targeted tissues through a multi-step process that begins with convection along the blood vessels and then movement from the blood vessels to the surrounding tissues by convection through the cellular interstices or molecular diffusion. Interstitial convection may be important in the margins of tumors where highly permeable blood vessels encounter high transmural pressures, but otherwise, transport from the blood vessels to the tissues progresses primarily by diffusion.

Copyright © 2013 by ASME

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