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An Automated Simulation Protocol for Exercise Physiology in Fontan Patients Using a Closed-Loop Lumped-Parameter Model

[+] Author Affiliations
Ethan Kung, Alison Marsden

University of California San Diego, San Diego, CAModeling of Congenital Hearts Alliance (MOCHA) Investigators, London, UK

Alessandro Giardini, Tain-Yen Hsia

Great Ormond Street Hospital for Children, London, UKModeling of Congenital Hearts Alliance (MOCHA) Investigators, London, UK

Francesco Migliavacca, Giancarlo Pennati

Politecnico di Milano, Milan, ItalyModeling of Congenital Hearts Alliance (MOCHA) Investigators, London, UK

Paper No. SBC2013-14366, pp. V01AT19A005; 2 pages
doi:10.1115/SBC2013-14366
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

Single ventricle physiology is one of the most severe forms of congenital heart disease in which an infant is born with only one functional pumping chamber. These patients must go through a series of surgical procedures concluding with the Fontan procedure, which connects the superior and inferior vena cavae to the pulmonary arteries, bypassing the right side of the heart entirely. Reduced exercise capacity is a common morbidity in Fontan patients1, leading to decreased quality of life, and the etiology of lowered exercise performance remains unclear. Exercise conditions place high demands on the cardiovascular system; any good surgical design must consider the behavior of the system at stress. Invasive clinical measurements during exercise pose many challenges and are typically not standard of care. There is a need to better understand Fontan exercise physiology and to predict clinical outcomes using computational tools.

Copyright © 2013 by ASME

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