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In Vitro Biocompatibility of Coaxial Electrospun Scaffolds for Cardiovascular Tissue Engineering

[+] Author Affiliations
Valerie M. Merkle, Kaitlyn R. Ammann, Katrina J. DeCook, Phat L. Tran, Marvin J. Slepian, Xiaoyi Wu

University of Arizona, Tucson, AZ

Paper No. SBC2013-14790, pp. V01AT17A028; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Coaxial electrospinning is a novel technique that allows the fabrication of composite nanofibers in a core-shell structure. This technique can be used to optimize the biological properties of a natural polymer (i.e. gelatin) and the mechanical properties of a synthetic polymer (i.e. polyvinyl alcohol). In this study, we fabricated coaxial nanofibers of gelatin and polyvinyl alcohol (PVA) for use in cardiovascular tissue engineering. Cellular adhesion and proliferation of human umbilical endothelial cells (HUVEC) and smooth muscle cells (SMC) is determined on coaxial nanofibers fabricated from a 1:1 and 3:1 (gelatin:PVA volumetric flow rate ratios), as well as nanofibers composed solely of gelatin or PVA. In addition, cellular migration on the coaxial nanofibers, gelatin nanofibers, and PVA nanofibers is determined for both endothelial cells and smooth muscle cells.

Copyright © 2013 by ASME



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