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A Novel Multi-Stimuli Bioreactor for Tissue Engineering Cartilage

[+] Author Affiliations
Carlos A. Carmona-Moran, Timothy M. Wick

University of Alabama at Birmingham, Birmingham, AL

Paper No. SBC2013-14586, pp. V01AT17A023; 2 pages
doi:10.1115/SBC2013-14586
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

The demand for tissue engineered articular cartilage for implantation in patients with osteoarthritis requires the development of stable and robust large scale production systems. This can be accomplished through the use of a bioreactor that applies mechanical loading and regulates nutrient transport to promote cell growth, cell differentiation and tissue production. In the present work we have developed a shear stress and perfusion bioreactor (SSPB) capable of providing multiple stimuli to facilitate large-scale production of tissue engineered cartilage.

Copyright © 2013 by ASME

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