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Contrasting the Thrombotic Phenotype of Donor-Matched Endothelial Outgrowth Cells and Endothelial Cells

[+] Author Affiliations
Jeremy J. Glynn, Monica T. Hinds

Oregon Health and Science University, Portland, OR

Paper No. SBC2013-14565, pp. V01AT17A020; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Despite the increasing burden of cardiovascular disease, vascular tissue engineering strategies have had limited success in achieving long-term patency in grafts less than 4 mm in diameter. Graft failure is often due to occlusion by thrombosis or intimal hyperplasia. Recognizing the capacity of endothelial cells (ECs) to properly coordinate these processes in vivo, much research has investigated the use of ECs to line the lumens of vascular grafts to improve patency (Zilla et al. 1994). However, the limited availability of autologous ECs and the donor site morbidity resulting from EC harvest has limited the clinical potential of these cellularized constructs.

Copyright © 2013 by ASME



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