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Fluid Dynamic Gauging-Based Assays for High-Throughput Investigation of Cellular Mechanotransduction

[+] Author Affiliations
Leah E. Worton, Sundar Srinivasan, Ronald Y. Kwon

University of Washington, Seattle, WA

Paper No. SBC2013-14394, pp. V01AT17A016; 2 pages
doi:10.1115/SBC2013-14394
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

Within bone, the mechanotransduction pathway is recognized as one of the primary pathways determining bone strength. However, despite an intense research effort over the last 30 years seeking to identify potential mechanosensing molecules in bone cells, only a handful of candidates have been identified. This is due in large part to the low throughput of existing mechanotransduction assays, which preclude them from powerful approaches for de novo discovery such as high-throughput screens and systems biology-based investigations.

Copyright © 2013 by ASME
Topics: Fluids , Assaying

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