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A Study on the Mechanical Properties of Acellular Dermal Matrices and Their Interface Properties After Implantation in an Acute Abdominal Wall Defect in a Primate

[+] Author Affiliations
P. G. De Deyne, T. Diab, M. Sandor

LifeCell Corporation, Bridgewater, NJ

Paper No. SBC2013-14339, pp. V01AT17A013; 2 pages
doi:10.1115/SBC2013-14339
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

Within Regenerative Medicine, non-cell-based approaches such as biologically-derived materials have been commercially successful and represent an important proportion of medically-used biomaterials1. Several acellular matrices are commercially available, to be used as a reinforcement of soft tissue where weakness exists. The goal of this study was to determine whether out-of-package mechanical properties of an acellular tissue matrix was predictive of its in vivo interface strength and whether the in vivo interface strength was associated with a particular histological response. We chose to test three porcine dermis-derived acellular matrices and one bovine pericardium derived matrix.

Copyright © 2013 by ASME

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