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Proliferation of Cells From a Mouse Model of Regeneration

[+] Author Affiliations
Kristen Lynch, Tabassum Ahsan

Tulane University, New Orleans, LA

Paper No. SBC2013-14305, pp. V01AT17A010; 2 pages
doi:10.1115/SBC2013-14305
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

The ability to induce limb regeneration in humans is of growing interest in the field of regenerative medicine, particularly due to the increased number of amputees among military veterans. Unfortunately, mammals have limited regenerative capabilities as compared to amphibians, which can re-establish complex structures after traumatic injury. There have been a few clinically documented cases of digit regeneration in children [1], indicating that the potential to regenerate is not completely absent in humans. Mammalian models of epimorphic regeneration is primarily limited to the mouse digit, which has a level-specific response in that amputation at the terminal phalangeal element (P3) results in regeneration, but not at the next more proximal joint (P2) (Figure 1). Recently primary stromal cells were isolated from each of these mouse joints (P3 and P2, respectively) [2], which provides a unique opportunity to utilize in vitro techniques to identify differences in one of the phenotypes prevalent at the amputation plane of a regenerating and non-regenerating region.

Copyright © 2013 by ASME

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