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Towards a Clinically Applicable Tissue Engineered Vascular Graft

[+] Author Affiliations
W. S. Sheridan, B. P. Murphy

Trinity College Dublin, Dublin, Ireland

O. Grant

Trinity College London, Dublin, Ireland

A. Lopez-Noriega

Royal College of Surgeons in Ireland, Dublin, Ireland

G. P. Duffy

Trinity College Dublin, Dublin, IrelandRoyal College of Surgeons in Ireland, Dublin, Ireland

Paper No. SBC2013-14457, pp. V01AT15A004; 2 pages
doi:10.1115/SBC2013-14457
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

Decellularized arterial tissue has shown promising use as a scaffold for vascular tissue replacement; similar structural and functional characteristics to the native tissue are maintained and these scaffolds are non-thrombogenic, non immunogenic with the ability to remodel and grow in vivo[1]. However, there still remains a number of limiting factors in clinically translating these scaffolds. Namely, producing a range of geometries to accommodate a large patient cohort within clinically feasible manufacturing times and costs. Furthermore, these scaffolds must be suitable for long term preservation to produce a reasonable shelf life and be capable of undergoing standard sterilization techniques.

Copyright © 2013 by ASME

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