0

Full Content is available to subscribers

Subscribe/Learn More  >

Retention and Transport of Hydrophobic and Hydrophilic Drug Surrogate Molecules in Coronary Arteries Measured Nondestructively With Photoacoustic Ultrasound

[+] Author Affiliations
Joseph T. Keyes, Leonardo G. Montilla, Russel S. Witte, Jonathan P. Vande Geest

The University of Arizona, Tucson, AZ

Paper No. SBC2013-14626, pp. V01AT14A006; 2 pages
doi:10.1115/SBC2013-14626
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

The design and implementation of local drug delivery mechanisms in cardiovascular applications provides a method by which localized action can occur without potentially problematic systemic effects. This has been especially relevant in the case of drug-eluting stents (DESs). It has been previously shown that the degree of chemical polarization can significantly change the degree of transport and the degree of vascular retention of drugs. Understanding how these differences occur in real-time, and nondestructively, can better help guide the design of such pharmaceuticals. Previous work by our laboratory has indicated differences in transport based on location within the coronary tree (Fig. 1) [1].

Copyright © 2013 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In