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Modeling Unstable Brain Aneurysms: MR Molecular Imaging of Myeloperoxidase in Vascular Wall and Correlation With Human Pathology

[+] Author Affiliations
Matthew J. Gounis, Imramsjah M. J. van der Bom, Ajay K. Wakhloo, Shaokuan Zheng, John P. Weaver, Ajit S. Puri, Ju-Yu Chueh, Anna Luisa Kuhn, Alexei A. Bogdanov, Jr.

University of Massachusetts Medical School, Worcester, MA

Paper No. SBC2013-14488, pp. V01AT14A005; 2 pages
doi:10.1115/SBC2013-14488
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

Brain aneurysm bleeding is associated with high rates of fatality or permanent neurological impairment. Despite the low risk of bleeding of an unruptured cerebral aneurysm (UCA) [1,2], the dismal outcome of aneurysmal rupture has led to the aggressive treatment of these aneurysms. In 2008, approximately 60,000 UCAs were treated in the USA [3]. The rate of morbidity and mortality from treatment is high: approximately 5 and 14% for coil embolization and surgical clipping, respectively [3]. The risk-benefit analysis does not support treatment of all UCAs and in an era of significant attention to healthcare economics, considerable expense for treatment of unruptured aneurysms may not be justified. Thus, there is a strong clinical need to identify asymptomatic patients with UCA who would benefit from preventative interventional or surgical procedures.

Copyright © 2013 by ASME

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