Full Content is available to subscribers

Subscribe/Learn More  >

Improved Assessment of Coronary Flow Impairment Using N-13 Ammonia Positron Emission Tomography

[+] Author Affiliations
Srikara Viswanath Peelukhana, Kranthi K. Kolli, Mohamed Effat, Imran Arif, Mariano Fernandez-Ulloa

University of Cincinnati, Cincinnati, OH

Hanan Kerr, Rupak K. Banerjee

University of Cincinnati, Cincinnati, OHVeteran Affairs Medical Center, Cincinnati, OH

Paper No. SBC2013-14351, pp. V01AT14A001; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Non-invasive diagnosis of coronary artery disease (CAD) is achieved using rest and stress myocardial perfusion imaging (MPI) techniques. Currently, the MPI technique that is a standard of care is the Single Photon Emission Computed Tomography (SPECT). However, comparatively accurate and reliable MPI diagnostic test known as Positron Emission Tomography (PET) is also available and gaining increasing popularity. In this study, a comparison is made between the impairments and left ventricular (LV) ejection fraction (EF) reported by SPECT and PET. In addition, using PET data, flow defects were quantified using coronary flow reserve (CFR: ratio of flow at stress to the rest) in four coronary territories, left ventricle (LV), left circumflex (LCX), right coronary artery (RCA) and left anterior descending (LAD). Three patients with previous SPECT and suspected CAD were consented and further assessed with a PET cardiac N-13 ammonia scan according to the study protocol. The comparisons of the two imaging modalities showed discordance for patients 1 and 2 while they concurred for the patient 3. More importantly, quantification of the extent of defect showed an abnormal CFR value (< 2) of 1.67 (LCX) and 1.57 (RCA) for the patient 1 and 1.67 (LAD) and 1.75 (RCA) for patient 2. For the third patient, CFR value was abnormal at 0.85 for the RCA. Therefore, in contrast to SPECT, quantification of flow impairment using PET MPI in individual coronary territories will aid in better diagnosis of CAD.

Copyright © 2013 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In