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In Vivo Measurements of Blood Transport Patterns and Stasis in the Human Left Ventricle

[+] Author Affiliations
Sahar Hendabadi, Shawn C. Shadden

Illinois Institute of Technology, Chicago, IL

Javier Bermejo, Yolanda Benito, Raquel Yotti, Francisco Fernández-Avilés

Hospital General Universitario Gregorio Marañón, Madrid, SpainInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

Juan C. del Álamo

University of California San Diego, La Jolla, CA

Paper No. SBC2013-14665, pp. V01AT13A023; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Because the left ventricle (LV) is not completely emptied during systole, oxygenated blood from the left atrium interacts with residual blood from preceding cycles. It is hypothesized that LV flow is optimal for transporting blood under normal conditions; yet proving this remains a challenge. Furthermore, clinical evaluation of LV hemodynamics has tremendous diagnostic importance for patients with cardiomyopathy. We have performed Doppler-echocardiography on 6 patients with dilated cardiomyopathy and 6 healthy volunteers. Using novel processing of the color-Doppler data, bi-directional velocity field maps in the apical long axis plane were derived. Resulting flow data was used to perform Lagrangian coherent structure (LCS) computation, which enabled novel characterization of the transport topology in the LV during filling and ejection. This framework was used to quantify stasis in the LV, which can be used as a surrogate for diagnosing pumping deficiencies and thrombosis risk. This framework also enables characterization of LV vortices, which have previously received much attention using Eulerian characterizations. The framework presented here uncovers the well-defined boundaries to both E-wave and A-wave filling vortices, which has not been previously reported.

Copyright © 2013 by ASME
Topics: Blood



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