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High-Throughput Microtissue Contractility Assay for In Vitro Analysis of Vascular Mechanics

[+] Author Affiliations
Eric S. Hald, Zaw Win, Marianne R. Scheitel, Patrick W. Alford

University of Minnesota-Twin Cities, Minneapolis, MN

Paper No. SBC2013-14604, pp. V01AT13A022; 2 pages
doi:10.1115/SBC2013-14604
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

Vascular smooth muscle (VSM) plays a key role in regulation of vascular mechanics through modulation of contractile tone. Studies suggest that mechanical or biochemical perturbation can lead to dysfunctional VSM behavior [1, 2]. This aberrant contractility may play a role in vascular dysfunction ranging from cerebral vasospasm to aneurysm genesis.

Copyright © 2013 by ASME
Topics: Muscle , Aneurysms

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