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Constitutive Modeling of Biaxial Mechanical Response of Arteries Subjected to Gradual Elastin Degradation

[+] Author Affiliations
Shahrokh Zeinali-Davarani, Ming-Jay Chow, Raphaël Turcotte

Boston University, Boston, MA

Katherine Yanhang Zhang

Boston University, Boston, MAMassachusetts General Hospital, Harvard Medical School, Boston, MA

Paper No. SBC2013-14318, pp. V01AT13A010; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


The passive mechanical response of arteries is believed to be mainly dominated by elastin and collagen fibers. Many arterial diseases are accompanied by significant changes in quantity and as well as the microstructure of these constituents due to the mechanical and biological adaptive processes. In this study we focus on the biaxial tensile test data of elastase-treated porcine aortic tissues [1]. We study the mechanical behavior of aortic tissues under gradual elastin degradation through constitutive modeling and associate the mechanical response with the microstructure of collagen observed in the microscopic images of fresh and digested tissues.

Copyright © 2013 by ASME
Topics: Modeling



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