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Investigation of the Spatial Structure of the Microcirculation in a Capillary Bundle From Rat Spinotrapezius Muscle Tissue

[+] Author Affiliations
Frank G. Jacobitz, Niki L. Yamamura

University of San Diego, San Diego, CA

Geert W. Schmid-Schönbein

University of California, San Diego, La Jolla, CA

Paper No. SBC2013-14107, pp. V01AT13A003; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


The microcirculation in the fascia of rat spinotrapezius muscle is studied using a computational approach that accounts for the shear- and hematocrit-dependent rheology of blood [1]. The simulations are based on a realistic network reconstruction derived from microscopic images of the fascia. The model includes fundamental aspects about passive properties of microvessels [5] as well as active myogenic constriction in arterioles [2]. We also present the development of a software tool to perform a spatial analysis of the hemodynamic results. This tool provides local information about the flow properties within a spatial microvessel network map in order to optimize the comparison with experiments. A review can be found in [4].

Copyright © 2013 by ASME



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