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Assessment of the Vascular and Trabecular Microstructures Using Micro Computed Tomography, Vascular Network Perfusion, and Image Registration Techniques

[+] Author Affiliations
Wei-Ju Tseng, Beom Kang Huh, Chantal de Bakker, Shiming Luo, Ling Qin, X. Sherry Liu

University of Pennsylvania, Philadelphia, PA

Hainan Zhu

University of Pennsylvania, Philadelphia, PAShanghai Jiao Tong University, Shanghai, China

Juyu Tang

Xiangya Hospital Central South University, Changsha, Hunan, China

Paper No. SBC2013-14699, pp. V01AT09A024; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Bone is a dynamic organ that constantly undergoes remodeling throughout one’s life. The remodeling process is required to repair damaged bone tissue and more importantly, to regulate calcium and phosphate homeostasis through the osteocytic network in conjunction with the microvascular network within bone marrow. Recently, techniques combining micro computed tomography (μCT) imaging with vascular network perfusion were developed to allow for 3-D visualization of the bone vascular network structure [1]. However, simultaneous visualization of the trabecular and vascular microstructures using standard μCT remains challenging, and thus the precise relationships between blood vessel formation and trabecular remodeling, as well as the impact of these relationships on metabolic bone diseases such as osteoporosis, remain unclear.

Copyright © 2013 by ASME



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