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Dependence of Human Lumbar Vertebral Trabecular Bone (HVTB) Mechanical Anisotropy Ratio on QCT–Based Apparent Density

[+] Author Affiliations
Ameet Aiyangar

EMPA Swiss Federal Laboratories for Materials Science and Technology, Zurich, Switzerland

Juan Vivanco

University of Wisconsin-Madison, Madison, WIUniversidad Tecnica Federico Santa Maria, Valparaiso, Chile

Anthony Au

VibeDx Diagnostic Corporation, Edmonton, AB, Canada

Paul Anderson, Everett Smith, Heidi-Lynn Ploeg

University of Wisconsin-Madison, Madison, WI

Paper No. SBC2013-14274, pp. V01AT09A014; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Obtaining bone mechanical properties from clinical resolution quantitative computed tomography (QCT)-derived localized apparent density presents the most attractive, available tool for developing subject-specific finite element (FE) bone models. While QCT density is a good predictor of the mechanical properties of HVTB [1, 2], knowledge of the fabric tensor (anisotropy ratio) can substantially improve prediction [3] and accuracy of CT-based continuum FE models [4]. Unfortunately, resolution of currently available clinical CT scanners is inadequate for mapping the fabric tensor of HVTB, which is known to be at least transversely isotropic [5]. Furthermore, trabecular bone mechanical anisotropy ratio has been shown to vary with density [2].

Copyright © 2013 by ASME
Topics: Density , Anisotropy , Bone



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