Full Content is available to subscribers

Subscribe/Learn More  >

Simulation and Analysis of a Flow Profile and Reaction Rate Within a 3D Microfluidic Cell Culture Array

[+] Author Affiliations
A. H. Rezwanuddin Ahmed, Zeynep Dereli Korkut, H. Dogus Akaydin, Sihong Wang

The City College of the City University of New York, New York, NY

Paper No. SBC2013-14737, pp. V01AT07A024; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Microfluidic devices deliver the promise of high throughput data output over conventional cell cultures with significantly smaller sample sizes[1]. The 3D microenvironment of sample cells provides with a more relevant analog to the realistic nature of cells over 2D cultures[2]. A microfluidic device of three layers to emulate the blood vessel, the basal membrane, and aggregates of tumor cells was developed using microfabrication technologies with Polydimethylsiloxane (PDMS) [3]. Such a 3D separation of the different layers is necessary in order to understand the dynamics of tumor cells with respect to drug responses[4]. In this study, we examine the flow patterns and transport issues in the 3D layered microfluidic device that mimicks the tumor microenvironment.

Copyright © 2013 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In