0

Full Content is available to subscribers

Subscribe/Learn More  >

A Virtual Test Bench to Study Transport Phenomena in 3D Porous Scaffolds Using Lattice Boltzmann Simulations

[+] Author Affiliations
Francesco Pennella, Piergiorgio Gentile, Marco A. Deriu, Diego Gallo, Gianluca Ciardelli, Alberto Audenino, Umberto Morbiducci

Politecnico di Torino, Turin, Italy

Alessandro Schiavi

INRIM, Turin, Italy

Eric Lorenz, Alfons G. Hoekstra

University of Amsterdam, Amsterdam, Netherlands

Paper No. SBC2013-14489, pp. V01AT07A020; 2 pages
doi:10.1115/SBC2013-14489
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

In tissue engineering (TE), scaffolds are widely used to provide a suitable and native-like environment for cell growth, organization, and proliferation. Microstructure of TE scaffolds is fundamental to the cell attachment and in-depth penetration, in conjunction with biological factors as cell seeding and nutrients supply. In particular, several studies have established that an adequate transport of nutrient through the scaffold is fundamental for culturing cells [1]. Hence, the easiness at which fluids/species move through the scaffold and friction forces exherted from fluid motion, have a marked impact in TE processes [2]. Mass transport through scaffolds is a phenomenon that can be described at different scales, the molecular level (nanoscale), the single-pore dimension level (microscale) and the whole-sample level (macroscale). In this work we present a virtual test bench where realistic 3D models of porous TE scaffolds are reconstructed from micro-CT images and the transport phenomena through them is simulated in silico by applying the Lattice Boltzmann Method (LBM). The final aim is to create an effective in silico tool suitable to study and optimize transport phenomena of porous scaffolds. The application of the LBM is justified by its versatility in simulating flows in irregular porous media (i.e. simplicity of handling complex boundaries) and in providing insights into transport properties such as permeability [3–4] and physical quantities as the shear stress, which are barely achievable experimentally [2]. Here, the virtual tool is applied to evaluate the performance of three biomimetic bioactive glass/polymer composite porous scaffolds for bone tissue regeneration with well-known mechanical and chemical properties, but never characterized in terms of transport phenomena. The in silico results are macroscopically validated in terms of permeability (kC) by comparison with experimental permeability (kE) measurements obtained by means of a dedicated test bench, very recently proposed for the characterization of porous media [5].

Copyright © 2013 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In