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Synthesis of Poly (L-Lactic Acid) Scaffolds Under Controlled Freezing Conditions

[+] Author Affiliations
Harish Chinnasami, Daniel Hayes, Ram Devireddy

Louisiana State University, Baton Rouge, LA

Paper No. SBC2013-14168, pp. V01AT07A009; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Poly (l-lactic acid) (PLLA) scaffolds for bone grafts were prepared by using Thermally Induced Phase Separation (TIPS) method. Solutions of PLLA-dioxane was formed by dissolving a pre-determined value of PLLA in dioxane (3, 7 and 10% wt/vol) at 323K. These solutions were frozen at controlled cooling rates (1, 10 and 40°C/min) in cylindrical capsules. The frozen solutions were freeze-dried for a period of 48 hours for the frozen dioxane to completely sublimate, leaving the porous PLLA scaffold. The scaffolds which were formed under different processing conditions were characterized in terms of porosity, pore sizes and compressive moduli.

Copyright © 2013 by ASME



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