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Increasing the Removal Efficiency of CPAs by the Dilution-Concentration Method: Adaptive Optimization of Diluent Flow Rates

[+] Author Affiliations
Heyuan Qiao, Weiping Ding, Gang Zhao

University of Science and Technology of China, Hefei, Anhui, China

Sijie Sun

University of Washington, Seattle, WA

Dayong Gao

University of Science and Technology of China, Hefei, Anhui, ChinaUniversity of Washington, Seattle, WA

Paper No. SBC2013-14160, pp. V01AT07A008; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


A dilution-concentration method for removing cryoprotective agents from cryopreserved blood was proposed in our previous work. In this study, the method was optimized adaptively by adjusting diluent flow rates. In the optimization, the diluent flow rate was set to vary with time, the tendency of which was designed to automatically minimize the washing time whereas the volume maximum of red blood cells was guaranteed below the upper tolerance limit. The results show that the optimized diluent flow rate decreases firstly and then increases rapidly. By doing so, the washing time is reduced by about 50%. In practice, the optimization strategy presented here will be very useful in the rapid preparation of cryopreserved blood for clinical use.

Copyright © 2013 by ASME



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