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Reducing the Osmotic Damage of RBCs During the Removal of CPAs From Cryopreserved Blood by the Dilution-Concentration Method: Extended Dilution Region

[+] Author Affiliations
Liangquan Gong, Weiping Ding, Gang Zhao

University of Science and Technology of China, Hefei, Anhui, China

Sijie Sun

University of Washington, Seattle, WA

Dayong Gao

University of Science and Technology of China, Hefei, Anhui, ChinaUniversity of Washington, Seattle, WA

Paper No. SBC2013-14112, pp. V01AT07A006; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


In this work, the dilution-concentration method proposed in our previous work is optimized to reduce the osmotic damage of red blood cells during the process of removing cryoprotective agents from cryopreserved blood. In the optimization, the dilution region i.e. the tubing length from the dilution point to the concentration point is extended so that the negative accumulation effect of the volume change of red blood cells can be allivated. By doing this, the volume maximum of red blood cells experienced during the removal of cryoprotective agents can be decreased and thereby the osmotic damage of red blood cells can be reduced.

Copyright © 2013 by ASME
Topics: Blood



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